Donor predicted heart mass as predictor of primary graft dysfunction

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Procalcitonin, a donor-specific predictor of early graft failure-related mortality after heart transplantation.

BACKGROUND To date, donor-specific markers to predict outcome after heart transplantation (HTx) are unknown. Increased procalcitonin (PCT) levels have been found in infectious inflammation with systemic reactions and/or poor organ perfusion but have not been studied in heart donors. We evaluated PCT as a predictor of early graft failure-related mortality after HTx. METHODS AND RESULTS PCT and...

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Cyclosporin-induced haemolytic-uraemic syndrome presenting as primary graft dysfunction.

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Biomarkers of cellular apoptosis and necrosis in donor myocardium are not predictive of primary graft dysfunction.

Primary graft dysfunction (PGD) is a life-threatening complication among heart transplant recipients and a major cause of early mortality. Although the pathogenesis of PGD is still unclear, ischemia/reperfusion injury has been identified as a predominant factor. Both necrosis and apoptosis contribute to the loss of cardiomyocytes during ischemia/reperfusion injury, and this loss of cells can ul...

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Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation.

Lung transplantation is the treatment of choice for end-stage pulmonary diseases. A limited donor supply has resulted in 4,000 patients on the waiting list. Currently, 10-20% of donor organs offered for transplantation are deemed suitable under the selection criteria, of which 15-25% fail due to primary graft dysfunction (PGD). This has spawned efforts to re-examine the current selection criter...

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[Donor/recipient age index (DoRAIn) as an independent predictor of long-term living-donor renal graft function].

PROBLEM The effect of donor/recipient age disparity on living-donor renal graft function is controversial. The objective of this study is to find new clinical predictors of renal graft function and evaluate the effect of donor/recipient age disparity in our series. METHODS A retrospective review of our institutional renal transplantation database was performed. We calculated the glomerular fi...

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ژورنال

عنوان ژورنال: The Journal of Heart and Lung Transplantation

سال: 2018

ISSN: 1053-2498

DOI: 10.1016/j.healun.2018.03.009